ea0007p172 | Reproduction | BES2004
Stubbs S
, Zachery-Jennings C
, Margara R
, Trew G
, Lavery S
, Stark J
, Hardy K
, Franks S
Early follicular development in polycystic ovaries (PCO) is abnormal; a higher proportion of follicles have entered the growing phase than in normal ovaries [1]. IGF-I stimulates the initiation of preantral follicle growth in a human tissue culture system using a growth factor-reduced extracellular matrix, Matrigel [2]. The aim of this study was to compare the effects of IGF-I on early preantral follicle development in polycystic and normal ovaries. Small ovarian cortical biop...